KMID : 1200020130370010001
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Diabetes & Metabolism Journal 2013 Volume.37 No. 1 p.1 ~ p.21
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AMPK and Exercise: Glucose Uptake and Insulin Sensitivity
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O¡¯Neill Hayley M.
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Abstract
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AMPK is an evolutionary conserved sensor of cellular energy status that is activated during exercise. Pharmacological activation of AMPK promotes glucose uptake, fatty acid oxidation, mitochondrial biogenesis, and insulin sensitivity; processes that are reduced in obesity and contribute to the development of insulin resistance. AMPK deficient mouse models have been used to provide direct genetic evidence either supporting or refuting a role for AMPK in regulating these processes. Exercise promotes glucose uptake by an insulin dependent mechanism involving AMPK. Exercise is important for improving insulin sensitivity; however, it is not known if AMPK is required for these improvements. Understanding how these metabolic processes are regulated is important for the development of new strategies that target obesity-induced insulin resistance. This review will discuss the involvement of AMPK in regulating skeletal muscle metabolism (glucose uptake, glycogen synthesis, and insulin sensitivity).
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KEYWORD
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AMPK, Exercise, Glucose uptake, Insulin resistance, Obesity
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